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Ternary Interactions

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Cooperative inhibitor binding
Thermofluor can detect multiple binding events and cooperativity in protein ligand binding interactions.
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Multiple ligand binding effects with thermofluor
Thermofluor can be an efficient means to discriminate the ability of ligands to induce additional binding events (e.g. for nuclear hormone receptor interactions).
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NHR Binding Interactions
Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds. Abad MC, et.al. Steroid Biochem Mol Biol. 2008 Jan;108(1-2):44-54. [X-ray crystal structures of NHR ligands found using thermofluor screening] PMID: 17964775
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