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Publications: Top Citations 2012
This page shows a list of top citations from 2012. It makes some interesting comparisons with the data from 2018.
Stacks Image 784

These statistics were originally compiled 09/2012

E primarily refers to an experimental result.
M primarily refers to an experimental tool or methodology.
T primarily refers to a theoretical observation based on structure or simulation.

Number Citations, Publication Number, Type (E-M-T), Publication Year, Title

798

53

E
1989

Structural Origins of High Affinity Biotin Binding to Streptavidin

444

47

M
1987

Use of an Imaging Proportional Counter in Macromolecular Crystallography

299

9

T
1976

A Hypothetical Structure for an Intermolecular Electron Transfer Complex of Cytochromes c and  b5.

262

89

M
2001

High Density Miniaturized Thermal Shift Assay as a General Strategy for Drug Discovery

200

10

T
1977

Structure and Function of Cytochrome c.

184

6

E
1973

The Structure of Oxidized Cytochrome c2 of Rhodospirillum rubrum.

173

72

E
1992

Crystallographic and Thermodynamic Comparison of Natural and Synthetic Ligands Bound  to Streptavidin  

169

18

T
1980

Structural and Functional Diversity in 4- a-Helical Proteins.

150

95

M
2005

Thermodynamic Stability Of Carbonic Anhydrase: Measurements Of Binding Affinity And Stoichiometry Using Thermofluor

149

40

E
1985

The Structure of Ferricytochrome c' from Rhodospirillum molischianum at 1.67 Å Resolution

135

31

T
1983

Structural Properties of Protein ß-Sheets

131

7

T
1973

Structural Bases for Function in Cytochrome c:  An Interpretation of Comparative X-ray and Biochemical Data. 

130

51

E
1989

Protein Crystal Growth in Microgravity

125

45

T
1987

Molecular Dynamics of a Cytochrome c-Cytochrome b5 Electron Transfer Complex

123

91

M
2003

Applications of Calorimetric Methods to Drug Discovery and the Study of Protein Interactions

116

3

M
1972

A Free Interface Diffusion Technique for the Crystallization of Proteins for X-ray Crystallography.

112

90

M
2002

Combinatorial Informatics in the Post-Genomics Era

105

29

T
1982

The a-Helix Dipole Model and Electrostatic Stabilization of a 4- a-Helical Proteins.

100

85

T
1999

Advances in diversity profiling and combinatorial series design.

86

60

T
1990

Competitor Analogs for Defined T Cell Antigens: Peptides Incorporating a Putative Binding Motif and Polyproline or Polyglycine Spacers

85

33

T
1983

Electrostatic Orientation During Electron Transfer Between Flavodoxin and Cytochrome c

78

76

E
1994

Structure-Based Design of Synthetic Azobenzene Ligands for Streptavidin

76

52

T
1989

Molecular Dynamics Simulation of a Phospholipid Micelle

60

20

E
1981

Crystallographic Structure of Rhodospirillum molischianum Ferricytochrome c' at 2.5 Å Resolution.

55

59

T
1990

A Molecular Dynamics Investigation of the Elastomeric Restoring Force in Elastin

54

81

M
1997

Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery

37

94

M
2005

Decrypting the Biochemical Function of an Essential Gene from Streptococcus pneumoniae using Thermofluor Technology

35

22

T
1981

Conformational and Geometrical Properties of ß - Sheets in Proteins. III.  Isotropically Stressed Configurations.

34

66

T
1991

The Identification of Tyrosine as a Common Key Residue in Unrelated H-2Kd Restricted Antigenic Peptides

29

17

T
1979

Conformations of Twisted Parallel ß-Sheets and the Origin of Chirality in Protein Structures.

29

21

T
1981

On the Evolutionary Relationship of 4- a-Helical Heme Proteins.

28

78

E
1995

Crystallographic and Thermodynamic Comparison of Structurally Diverse Molecules Binding to Streptavidin

25

13

T
1977

Structural Convergence During Protein Evolution

23

82

E
1998

In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors. 

22

27

T
1982

A Model for Catabolite Activator Protein Binding to Supercoiled DNA

22

48

E
1988

Molecular Factors Stabilizing Protein Crystals

22

73

T
1992

PROBIT: A Statistical Approach to Modeling Proteins from Partial Coordinate Data Using Substructure Libraries

21

93

M
2003

Chemical Genomics as an Emerging Paradigm for Postgenomic Drug Discovery

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