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Page last updated: 1/4/19

Publications: Top Citations 2018

My favorite quote from Freeman Dyson:
"Most of the crackpot papers which are submitted to The Physical Review are rejected, not because it is impossible to understand them, but because it is possible. Those which are impossible to understand are usually published. When the great innovation appears, it will almost certainly be in a muddled, incomplete and confusing form. To the discoverer himself it will be only half-understood; to everybody else it will be a mystery. For any speculation which does not at first glance look crazy, there is no hope."

Still, this is mostly true for theoretical physics.

Although great significance is attached to citation frequency in the academic scientific world, it is sometime difficult to know what drives interest in an individual publication. Some are review articles that are written at the right moment. Some present new results in hot areas of emerging science. Other publications describe experiments that yield interesting results, more or less by accident. Others describe work that enable others to do new experiments, or better, that make a hypothetical proposition that motivates new experiments. Still, as anyone with experience will attest, many innovative ideas go unappreciated.

Top 40 Citations

These stats were updated on 11/2018

Data from Google Scholar

E primarily refers to an experimental result.
M primarily refers to an experimental tool or methodology.
T primarily refers to a theoretical observation or molecular modeling study based on structure or simulation.
R denotes a review-style article
P denote an issued patent

Rank, Publication Number, Type (E-M-T-R-P), Publication Year, Number Citations, Title

1	53	E	1989	1319	Structural Origins of High Affinity Biotin Binding to Streptavidin.
2	89	M	2001	730	High Density Miniaturized Thermal Shift Assay as a General Strategy for Drug Discovery.
3	47	M	1987	611	Use of an Imaging Proportional Counter in Macromolecular Crystallography.
4	95	E	2005	402	Thermodynamic Stability Of Carbonic Anhydrase: Measurements Of Binding Affinity And Stoichiometry Using Thermofluor.
5	9	T	1976	363	An Hypothetical Structure for an Intermolecular Electron Transfer Complex of Cytochromes c and b5.
6	10	R	1977	303	Structure and Function of Cytochrome c.
7	P1	P	1995	277	System and method of automatically generating chemical compounds with desired properties US Patent 5,463,564
8	72	E	1992	274	Crystallographic and Thermodynamic Comparison of Natural and Synthetic Ligands Bound to Streptavidin.
9	6	E	1973	246	The Structure of Oxidized Cytochrome c2 of Rhodospirillum rubrum.
10	18	T	1980	241	Structural and functional diversity in 4-α-helical proteins
11	31	R	1983	224	Structural properties of protein β-sheets
12	91	R	2003	205	Applications of calorimetric methods to drug discovery and the study of protein interactions
13	51	E	1989	204	Protein Crystal Growth in Microgravity.
14	3	M	1972	198	A Free Interface Diffusion Technique for the Crystallization of Proteins for X-ray Crystallography.
15	40	E	1985	194	Structure of ferricytochrome c′ from Rhodospirillum molischianum at 1.67 Å resolution
16	7	R	1973	179	Structural Bases for Function in Cytochrome c: An Interpretation of Comparative X-ray and Biochemical Data.
17	45	T	1987	175	Molecular dynamics of a cytochrome c-cytochrome b5 electron transfer complex
18	29	T	1982	162	alpha-Helix dipole model and electrostatic stabilization of 4-alpha-helical proteins
19	P5	P	2000	141	Microplate thermal shift assay for ligand development and multi-variable protein chemistry optimization US Patent 6,020,141
20	90	M	2002	139	Combinatorial informatics in the post-genomics era
21	30	E	1982	138	Transient kinetics of electron transfer reactions of flavodoxin: ionic strength dependence of semiquinone oxidation by cytochrome c, ferricyanide, and ferric EDTA and computer ...
22	P2	P	1996	123	System and Method of Automatically Generating Chemical Compounds with Desired Properties. US Patent No. 5,574,656
23	P6	P	2000	120	Microplate thermal shift assay apparatus for ligand development and multi- variable protein chemistry optimization US Patent 6,036,920
24	52	T	1989	115	Molecular dynamics simulation of a phospholipid micelle
25	33	T	1983	114	Electrostatic orientation during electron transfer between flavodoxin and cytochrome c
26	85	R	1998	111	Advances in diversity profiling and combinatorial series design
27	76	E	1994	107	Structure-based design of synthetic azobenzene ligands for streptavidin
28	P18	P	2003	102	Microplate Thermal Shift Assay For Ligand Development using 5'(4"Dimethylamino-Phenyl)-2-(4'-Phenyl) Oxazole Derivative Fluorescent Dyes. US Patent No. 6,569,631
29	P3	P	1997	99	System, Method and Computer Program Product For At Least Partially Automatically Generating Chemical Compounds Having Desired Properties. US Patent No. 5,684,711
30	19	E	1980	96	Structure of cytochrome c′: a dimeric, high-spin haem protein
31	60	T	1990	95	Competitor analogs for defined T cell antigens: peptides incorporating a putative binding motif and polyproline or polyglycine spacers
32	P15	P	2002	92	System, method and computer program product for identifying chemical compounds having desired properties US Patent No. 6,421,612
33	22	T	1981	86	Conformational and geometrical properties of β-sheets in proteins: I. Parallel β-sheets
34	23	T	1981	85	Conformational and geometrical properties of β-sheets in proteins: II. Antiparallel and mixed β-sheets
35	81	R	1997	83	Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery
36	59	T	1990	83	A molecular dynamics investigation of the elastomeric restoring force in elastin
37	P4	P	1999	79	System, Method and Computer Program Product For At Least Partially Automatically Generating Chemical Compounds with Desired Properties from a List of Potential Chemical Compounds to Synthesize. US Patent No. 5,901,069
38	P19	P	2003	77	Method, System and Computer Program Product for Non-Linear Mapping of Multi-Dimensional Data. US Patent No. 6,571,227
39	20	E	1981	75	Crystallographic structure of Rhodospirillum molischianum ferricytochrome c ′ at 2.5 Å resolution
40	11	E	1977	75	Structure of cytochrome c555 of Chlorobium thiosulfatophilum: primitive low- potential cytochrome c

See Sequential List for Downloads

This data makes and interesting comparison with Top Citation Data from 2012

Top Citations 2012